Each ingredient in Virilion has been carefully selected based on strong scientific research and clinical evidence. Below, you’ll find summaries of studies that support the inclusion of each ingredient at the specific dosage used in Virilion. These studies demonstrate benefits in key areas such as testosterone support, libido, erectile function, stress resilience, and overall male vitality.
Saffron
Clinical studies often use 200 mg/day of whole saffron stigma, but Virilion uses a 5:1 extract — meaning 30 mg provides the active compounds found in approximately 150 mg of dried saffron. This makes our dose closely aligned with clinical ranges, while ensuring standardised, consistent results.
- Shamsa et al. (2009): 200 mg/day of saffron for 10 days improved erectile function and nocturnal penile tumescence in men with ED.
- Hausenblas et al. (2015): This systematic review evaluated saffron’s effects on sexual dysfunction. Across multiple randomized controlled trials, saffron significantly improved erectile function, sexual desire, arousal, and satisfaction in both men and women. Doses around 30 mg/day were effective, supporting Virilion’s inclusion of a 30 mg/day 5:1 extract.
Tongkat Ali
Most studies use 200–300 mg/day of Tongkat Ali extract. Virilion uses 250 mg/day of a 200:1 extract — equivalent to 50,000 mg of root — and standardised to 2% eurycomanone, the key active compound. Many competitor products use raw powder or low-potency extracts, while our dose aligns directly with clinically supported levels.
- Ismail et al. (2012): 300 mg/day enhanced libido, sperm motility, and testosterone.
- Talbott et al. (2013): 200 mg/day improved testosterone-to-cortisol ratio in stressed men.
Ashwagandha
Clinical trials often use 600 mg/day of full-spectrum ashwagandha extracts like KSM-66, providing up to 30 mg of withanolides daily. Virilion delivers 300 mg of a 10:1 extract standardised to 2.5% withanolides, supplying 7.5 mg/day — a meaningful dose that aligns with studies showing benefits for stress, cortisol, and male vitality, particularly in combination with other adaptogens.
- Chandrasekhar et al. (2012): 600 mg/day reduced stress and serum cortisol in 60-day trial.
- Wankhede et al. (2015): 600 mg/day improved testosterone and strength in exercising men.
Horny Goat Weed
Most brands use raw herb or low-icariin extracts (2–5%). Virilion delivers 22 mg of pure icariin daily — a high-potency nitric oxide booster. While few studies use icariin alone, those that include Epimedium blends show positive effects, and Virilion’s extract is among the strongest available in natural supplements.
- Ning et al. (2010): Icariin enhanced erectile function, nitric oxide activity, and nerve regeneration in a rat model of erectile dysfunction.
- González-Cadavid & Rajfer (2023): A review of icariin’s effects on male reproduction reported enhanced testosterone, sperm count, and fertility outcomes in mammalian studies.
Panax Red Ginseng
Studies typically use 1,000–3,000 mg of dried root, or 200–400 mg extract. Virilion’s 20:1 extract at 100 mg provides 2,000 mg dried root equivalent — with 24 mg of ginsenosides daily. This is a clinically relevant active dose aligned with studies showing benefits in energy, blood flow, and sexual function.
-
Jang et al. (2008): A double-blind, placebo-controlled study found that 3,000 mg/day of red ginseng extract powder significantly improved erectile function in men with mild to moderate ED over 12 weeks.
https://icurology.org/DOIx.php?id=10.4111%2Fkju.2009.50.2.159
- Teitelbaum et al. (2022): An open-label human trial using 100 mg/day of red ginseng combined with gamma-cyclodextrin showed significant improvements in energy and fatigue in individuals with chronic fatigue or fibromyalgia.
Zinc
Clinical improvements in testosterone have been seen with 5–10 mg/day when correcting deficiency. Virilion uses 7 mg from a bioavailable form (citrate), which matches ranges shown to support hormone function and male fertility.
- Prasad et al. (1996): Older men with marginal zinc deficiency doubled testosterone after supplementation.
- Liger et al. (2023): Confirmed positive effects on male fertility and testosterone when correcting deficiency.
Vitamin D3
Studies showing testosterone improvements use 1,000–3,332 IU/day. Virilion includes 1,000 IU as a safe, effective baseline — particularly beneficial for men with low sun exposure or suboptimal D3 status.
- Pilz et al. (2011): 3,332 IU/day improved testosterone over 1 year in vitamin D-deficient men.
Black Pepper
Clinical trials use 5–20 mg of piperine to enhance nutrient absorption. Virilion includes the upper end of this range (19 mg piperine) to maximise bioavailability of the herbal actives.
- Shoba et al. (1998): 20 mg Piperine increased absorption of curcumin by 2,000%.
